Experimental Vascular Pathology

Vascular Pathology

Atherosclerosis is a chronic but progressive vasculopathy characterized by subendothelial accumulation of lipids and fibrous constituents in middle sized and large arteries and the major substrate for cardiovascular disease. It becomes clinically manifest only at a late stage, generally through acute cardiovascular syndromes that are caused by rupture of an advanced, vulnerable plaque. Vulnerable plaques are typified by a large lipid core underlying a thin fibrous cap and abundant inflammatory cell deposits in their adventitia and shoulder regions.