Experimental Cancer Pathology
Experimental Vascular Pathology
From the beginning of 2022, for a term of 3-years, Dr. Emiel van der Vorst has been appointed as member of the “Scientists of Tomorrow” from the European Society of Cardiology (ESC).
The “Scientists of Tomorrow” (SoT) is a group of young, proactive, basic and clinical researchers, who work closely with the Council on Basic Cardiovascular Science to fulfil its mission in promoting and supporting basic science among young ESC members. Members of the "Scientists of Tomorrow" will contribute to the scientific, educational and advocacy activities of the ESC paving the way of its future.
For more information, please visit: https://www.escardio.org/The-ESC/ESC-Young-Community/Scientists-of-Tomorrow
Are you working with iron oxide nanoparticles/USPIO? Note: not all are inert in hyperlipidemia, but cause apoptosis in human and mouse atherosclerotic plaque foam cells. Work initiated by Erik Biessen in Leiden University/LACDR/Division of Biopharmaceutics finished in Maastricht University CARIM. Thanks to all contributors Filip Segers, Adele Ruder, Theo Van Berkel, Ilze Bot, Bente Halvorsen, Twan Lammers team, Eline Kooi, Geert Willem Schurink, and more. #atherosclerosis #mri #apoptosis #macrophages
Dr. Kim van Kuijk and Prof Judith Sluimer’s paper on macrophage oxygen sensors in #atherosclerosis is officially published in Cardiovascular Research! Big milestone: two papers online and 1 published in 1 week by the Sluimer lab.
Prof. Judith Sluimer organized a single cell sequencing workshop for novices on March 31 to stimulate use of the 10x chromium controller in CARIM, FHML. Maastricht University colleagues on Participants were happy with the initiative and lectures by bioinformatician Dr. Hayat (RWTH, Aachen), and two experts from 10xgenomics mr. Buermans and Dr. de Gelas. Save the date for workshop 2: a full day training on bioinformatics on July 16!
Frontiers in Cardiovascular Medicine published a special issue entitled "Proteolysis of Membrane Proteins in Vascular Biology and Disease" guest edited by Marjo Donners. Research topic description: The Regulated Intramembrane Proteolysis (RIP) is a tightly controlled 2-step process in which transmembrane proteins are cleaved. In the initial step, called ectodomain shedding, cleavage near the membrane leads to the release of the extracellular domain. This cleavage thus regulates surface expression of various membrane proteins, e.g. receptors, hence modulating cellular sensitivity for environmental stimuli or other intrinsic cell functions. On the other hand, many released ectodomains have (ant)agonistic functions acting in an autocrine or paracrine manner. RIP is implicated in various crucial processes, such as angiogenesis, inflammation, wound healing/tissue repair/fibrosis and thrombosis. This Research Topic provides original research as well as overview contributions that advance our understanding of the regulation and function of intramembrane proteolysis in the field of vascular biology.
Research within the Department of Pathology covers major topics in Oncology, Cardiovascular diseases, Neurology and Immunology and focuses both on basic and translational aspects.
All research programmes are embedded in the respective MUMC research institutes, i.e. GROW (School for Oncology and Developmental Biology) and CARIM (School for Cardiovascular Diseases).
For more information about the different research lines, see corresponding pages.