- Publication in Clinical and Translational Medicine
Jin et al. applied multi-omics machine learning algorithm on the Maastricht Human Plaque Study (MaasHPS) cohort consisting of transcriptomics, proteomics/peptidomics of more than 40 male carotid atherosclerotic samples, to study and discover the underlying dysregulated pathway that influences the human plaque stability. This study highlights the advantages of multi-omics analysis in terms of model robustness, biological significance and clinical translatability compared with single-omics analysis. Moreover, the identified SRF-regulated disease network in this study provides valuable new insights that expedite the design of targeted intervention in plaque rupture.
The study was carried out by Han Jin, Dr. Pieter Goossens and colleagues in the experimental vascular pathology group, under the supervision of Prof. Erik A.L. Biessen, and in collaboration with the Department of Data Science and Knowledge Engineering (Dr. Evgueni Smirnov and Dr. Joël M.H. Karel), the Maastricht Centre for Systems Biology (Dr. Martina Summer - Kutmon), the Department of Bioinformatics (Prof. Chris T.A. Evelo), and the Karolinska Institute (Prof. Ulf Hedin and Dr. Ljubica Matic). This is the first time we comprehensively analyze and publish the MaasHPS cohort.
Access the article here: https://onlinelibrary.wiley.com/doi/10.1002/ctm2.458
- PhD thesis defence Kim van Kuijk, 4th of June 2021
On the 4th of June 2021, Kim successfully defended her dissertation titled: The effect of intra- and extracellular challenges on cellular responses in atherosclerosis. Her PhD trajectory was performed under the supervision of Prof. Judith Sluimer, Prof. Erik Biessen and Prof. Andrew Baker. The thesis shed light on numerous stressors in the context of atherosclerosis. The two main players in the dissertation are immune cells, e.g. macrophages, and fibroblasts. In the thesis, the influence of different challenges such as oxygen and cholesterol levels were investigated and how beforementioned cells respond to these challenges. Her research showed that a variety of stressors can have divergent effects on atherosclerosis, in a cell-specific manner. Nowadays, more and more cell- and patient-specific treatments are being executed and the research in her thesis emphasizes the importance thereof.
- Grant of 1 Million for Dr. Emiel van der Vorst
The German Corona Stiftung has awarded Dr. Emiel van der Vorst (Experimental vascular pathology group and RWTH Aachen) a grant worth 1 Million euros for a period of 5 years. Dr. Van der Vorst and his group will explore the role of the Aryl-Hydrocarbon Receptor in lipid metabolism and atherosclerosis development.
The project will focus on the complex interplay between the liver-gut-vessels in the context of immune-lipid crosstalk fuelled by tissue-specific effects of the Aryl-Hydrocarbon Receptor. In addition, as the Aryl-Hydrocarbon Receptor is a main receptor for uremic toxins, its role will also be investigated in the context of chronic kidney disease driven atherosclerosis.
The recruiting process for new PhD-Students is currently ongoing. If you are interested, please feel free to contact me directly at: email@example.com
Research within the Department of Pathology covers major topics in Oncology, Cardiovascular diseases, Neurology and Immunology and focuses both on basic and translational aspects.
All research programmes are embedded in the respective MUMC research institutes, i.e. GROW (School for Oncology and Developmental Biology) and CARIM (School for Cardiovascular Diseases).
For more information about the different research lines, see corresponding pages.